Status:
UNKNOWN
Effect of Irrigation With Antibiotic-containing Solutions on Postoperative Pain and Intra-canal Bacteria
Lead Sponsor:
Cairo University
Conditions:
Necrotic Pulp
Eligibility:
All Genders
18-50 years
Phase:
PHASE4
Brief Summary
• The aim of this study is to compare the degree of postoperative pain and the antimicrobial effect in terms of bacterial count reduction after using co-amoxiclav-clindamycin solution versus MTAD and ...
Detailed Description
* After confirming the diagnosis and making sure that the patient conforms to all eligibility criteria, the principal investigator will enroll the patient in the study. * The operator will complete tr...
Eligibility Criteria
Inclusion
- Maxillary/mandibular single-rooted permanent teeth:
- Diagnosed clinically with pulp necrosis.
- Absence of spontaneous pain.
- Normal/slight widening in the periodontal membrane space (PMS).
- Patients' acceptance to participate in the trial.
- Patients who can understand numerical rating scale (NRS) and can sign the informed consent.
Exclusion
- Medically compromised patients: Pain levels and healing following treatment would be compromised as these patients show higher incidence of pain and lower healing rate.
- Patients with known allergy to penicillin or penicillin derivatives.
- Pregnant females: Avoid radiation exposure, anesthesia, and medication.
- If analgesics or antibiotics have been administrated by the patient during the past 24 hours preoperatively: Might alter their pain perception.
- Patients reporting bruxism or clenching: Avoid further pressure on an already inflamed tooth inducing subsequent irritation and inflammation.
- Teeth that show association with acute periapical abscess and swelling: Need special treatment steps which could involve additional visits with incision and drainage. Also, it could influence initiation and progression of postoperative pain.
- Greater than grade I mobility or pocket depth greater than 5mm. Need special surgical and/or periodontal therapy.
- Non-restorable teeth.
- Immature teeth.
- Radiographic evidence of periapical radiolucency, external or internal root resorption, vertical root fracture, perforation or calcification.
Key Trial Info
Start Date :
January 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2021
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT04035070
Start Date
January 1 2021
End Date
June 1 2021
Last Update
October 14 2020
Active Locations (1)
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1
Endodontic Department - Faculty of Dentistry - Cairo University
Cairo, Egypt