Status:
UNKNOWN
The Effectiveness of High-dose Intravenous Vitamin c With Very Low Carbohydrate Diet for Terminal Colon Cancer Patients
Lead Sponsor:
National Taiwan University Hospital
Conditions:
Colon Cancer Stage Iv
Eligibility:
All Genders
20+ years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose is to evaluate the effectiveness of high dose intravenous vitamin C (IVC) therapy plus very low carbohydrate diet (VLCD) for stage IV colon cancer (with KRAS and BRAF mutation ) with or wi...
Detailed Description
High dose IVC induces pro-oxidant effects, inhibits energy metabolism, acts as cytotoxic effect, and induces cancer cell apoptosis and necrosis. The recent advance in Warburg effect makes a new direct...
Eligibility Criteria
Inclusion
- stage IV colon cancer
- with KRAS and BRAF mutation
Exclusion
- G-6-PD deficiency,
- metastatic kidney disease,
- obstructive uropathy,
- nephrotic syndrome,
- under other alternative medicine treatment or intravenous vitamin treatment,
- pregnant or lactating women,
- impaired renal function with a serum creatinine ≥ 132.6µmol/L(1.5 mg/dL)
- significant fluid retention(pleural effusion, ascites, lower leg edema),
- terminal heart failure,
- incapability to make decision,
Key Trial Info
Start Date :
January 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2022
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04035096
Start Date
January 1 2020
End Date
June 30 2022
Last Update
July 29 2019
Active Locations (1)
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1
National Taiwan University Hospital
Taipei, Taiwan, 100