Status:
UNKNOWN
Application of MRI for Musculoskeletal Involvement in SLE
Lead Sponsor:
Hospital del Mar
Conditions:
Hand Rheumatism
Systemic Lupus Erythematosus Arthritis
Eligibility:
All Genders
Phase:
NA
Brief Summary
Articular involvement can reach up to 95% within the chronic multisystemic manifestations of SLE (1). Originally, a non-erosive pattern of articular inflammation was described, but the emergence of mo...
Detailed Description
BACKGROUND AND RATIONALE * Nowadays no valid classification system for SLE-related arthritis/tenosynovitis exists. * Data are not sufficient to establish an SLE-specific pattern of inflammatory invol...
Eligibility Criteria
Inclusion
- Patients affected by SLE (1982 revised criteria) with scheduled visits to the SLE specialized medical office at Hospital del Mar:
- (pain+ / synovitis +): SLE patients with inflammatory pain and synovitis determined by the practitioner during physical examination of radius and ulna carpal joint and/or carpus and/or metacarpophalangeal joint and/or IP . Defining synovitis as pain and inflammation and/or deformity (present or existing over the past year) included in the clinical history
- (pain + / synovitis -) SLE patients with inflammatory pain without determined synovitis . Current (or over the past year) pain in radius and ulna carpal joint and/or carpus and/or metacarpophalangeal joint and/or IP, with no synovitis
- (pain - / synovitis -) SLE patients without inflammatory pain with normal physical examination currently or over the past year
- Control patients, without SLE nor immediate relatives affected by systemic inflammatory diseases, who lack articular pain and have blood test with no elevation APR or autoimmunity +)
Exclusion
- Jaccoud's arthropaty
- RF + and/or ACPA +
- Incomplete SLE, MCTD, overlap syndromes
- Hand surgery
- Current neoplasia
- Non-rheumatoid systemic autoimmune diseases
- Contraindication for MRI
Key Trial Info
Start Date :
December 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2020
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04035265
Start Date
December 1 2018
End Date
May 1 2020
Last Update
July 31 2019
Active Locations (1)
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1
Hospital del Mar
Barcelona, Spain, 08003