Status:
UNKNOWN
Microcirculation and Plasticity After Stroke
Lead Sponsor:
University of Zurich
Conditions:
Stroke, Ischemic
Eligibility:
All Genders
18+ years
Brief Summary
Reperfusion is the main goal of early medical interventions after stroke, such as thrombolysis and thrombectomy. Recanalization works only if applied early - the earlier the better, but with a statist...
Eligibility Criteria
Inclusion
- ≤72h First-ever clinical ischemic stroke at hospital admission
- Occlusion of M1-segment of the middle cerebral artery, and/ or intracranial internal carotid artery, and perfusion deficits with cortical involvement
- 18 years or above
- Living independent before stroke (mRS ≤3)
- Written informed consent of the patient or the when the patient is not able to participate in the consenting procedure, the written authorization of an independent doctor who is not involved in the research project to safeguard the interests of the patient; in that case, post-hoc written informed consent of the patient is needed, or when the patient remains unable to participate in the informed consent procedure, written informed consent of a next of kind
Exclusion
- Major cardiac, psychiatric and/ or neurological diseases
- Early seizures
- Known or suspected non-compliance, drug and/ or alcohol abuse
- Contra-indications for Magnetic Resonance Imaging and Transcranial Magnetic Stimulation, such as a history of seizure, prior electroconvulsive therapy, deep brain stimulators or other metal in the head, skull defect, pacemaker; neuroleptic medication; known allergic reaction to contrast material
- Documented evidence that the patient does not want to participate in any scientific study or, in case of lack of documented evidence, no behavior and/or expression(s) that indicate(s) refusal of the patient to participate in research
Key Trial Info
Start Date :
October 7 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 31 2022
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT04035746
Start Date
October 7 2019
End Date
January 31 2022
Last Update
August 25 2020
Active Locations (1)
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1
University Hospital Zurich
Zurich, Switzerland, 8091