Status:
COMPLETED
Role of Aerobic Exercise to Modulate Cardiotoxicity in Long Term Cancer Survivors Exposed to Anthracycline Therapy
Lead Sponsor:
Connecticut Children's Medical Center
Collaborating Sponsors:
Nationwide Children's Hospital
Conditions:
Cancer
Cardiotoxicity
Eligibility:
All Genders
9-99 years
Brief Summary
Over 50% of the more than 270,000 childhood cancer survivors in the U.S. have been treated with anthracyclines and thus are at risk of developing cardiotoxicity. The impact of exercise training on LV ...
Detailed Description
The goal of this research is to assess the effect of exercise intervention on imaging parameters by CMR, cardiopulmonary indices and MicroRNA expression in survivors of childhood cancer exposed to ant...
Eligibility Criteria
Inclusion
- Long-term childhood cancer survivors greater than 9 years of age\*
- Exposed to anthracycline chemotherapy \* Age \> 9 years of age was chosen to avoid the need for general anesthesia or sedation
Exclusion
- Contraindications to CMRI\*
- Individuals needing sedation to complete the cMRI
- Subject not able to perform stress test.
- Pregnancy\*\*
- Non-English speaking individuals
- Orbital X-Ray confirmed to have metal in the eye or patient confirmed to have metal in the eye
Key Trial Info
Start Date :
June 19 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 27 2025
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT04036032
Start Date
June 19 2015
End Date
August 27 2025
Last Update
October 14 2025
Active Locations (2)
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1
CT Children's Medical Center
Hartford, Connecticut, United States, 06106
2
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205