Status:
RECRUITING
Imaging Synapses With [11C] UCB-J in the Human Brain
Lead Sponsor:
Davidzon, Guido, M.D.
Collaborating Sponsors:
Weston Havens Foundation
Conditions:
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer \[11C\]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia. This imaging method allo...
Eligibility Criteria
Inclusion
- 18 - 65 years in age
- For SZ participants:
- On a stable medication regimen for at least two weeks prior to testing
- A clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
- Able to complete a PET-MR scan without the use of sedation
Exclusion
- Active substance use within three months of testing
- IQ \< 70
- Major medical neurological illness or significant head trauma
- Pregnancy or breastfeeding
- Contraindication to MR scanning, including magnetic-resonance incompatible metal or hardware including pacemakers, cochlear implants, and bullets near a critical organ
- Weight \> 350 lbs or a large body habitus that MR scanner cannot accommodate
- History of or current claustrophobia
- Inability to comply with basic study requirements such as following directions and punctuality
- For HC participants:
- Presence of a first degree relative with a psychotic disorder
- Lifetime diagnosis of major psychiatric illness
- For SZ participants:
- Unstable psychiatric symptoms at the time of testing, e.g. acute suicidality, prominent psychosis, or behavioral dyscontrol
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04038840
Start Date
August 1 2019
End Date
December 1 2025
Last Update
December 16 2024
Active Locations (2)
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1
VA Palo Alto Health Care System
Palo Alto, California, United States, 94304
2
Stanford University
Stanford, California, United States, 94305