Status:

COMPLETED

Elagolix for Fertility Enhancement Clinical Trial

Lead Sponsor:

Wake Forest University Health Sciences

Collaborating Sponsors:

University of North Carolina, Chapel Hill

Stanford University

Conditions:

Endometriosis

Unexplained Infertility

Eligibility:

FEMALE

18-42 years

Phase:

PHASE2

Brief Summary

Studies suggest that undiagnosed endometriosis results in poor reproductive outcomes in the setting of In Vitro Fertilization and Embryo Transfer (IVF-ET). Biomarkers that predict endometriosis includ...

Detailed Description

Although meta-analyses have not demonstrated an effect of endometriosis on IVF outcomes, most women with endometriosis undergoing IVF have not been diagnosed or treated for their disease. Recent evide...

Eligibility Criteria

Inclusion

  • Anti-Mullerian Hormone (AMH) \> 0.5 and \< 10
  • At least 1 euploid embryo for transfer
  • Prior endometrial biopsy showing elevated BCL6 and SIRT1 expression
  • Endometrial thickness \> 5.9 and \< 14 mm

Exclusion

  • Uterine fibroids \> 4 cm (intramural)
  • Polycystic ovary syndrome (Rotterdam criteria)
  • Ovarian failure and donor eggs or oocytes
  • Positive lupus anticoagulant or positive anti-cardiolipin antibody testing
  • Diabetes mellitus (Type I or II)
  • Untreated hypothyroidism
  • Untreated hyperprolactinemia
  • BMI \<17 or \> 35
  • Uncorrected uterine anomaly

Key Trial Info

Start Date :

January 15 2022

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

August 9 2023

Estimated Enrollment :

10 Patients enrolled

Trial Details

Trial ID

NCT04039204

Start Date

January 15 2022

End Date

August 9 2023

Last Update

July 26 2024

Active Locations (1)

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1

Wake Forest Univesity Health Sciences

Winston-Salem, North Carolina, United States, 27157