Status:
UNKNOWN
Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery
Lead Sponsor:
King's College Hospital NHS Trust
Collaborating Sponsors:
London School of Hygiene and Tropical Medicine
Guy's and St Thomas' NHS Foundation Trust
Conditions:
Coronary Heart Disease
Cardiovascular Diseases
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The objective of this research proposal is to find out whether comparing the two different anaesthetic maintenance techniques (Propofol vs volatile anaesthetics) in adult patients undergoing heart sur...
Detailed Description
All patients undergoing heart bypass surgery are given anaesthetics during the operation. There are two types of anaesthetic commonly given to patients undergoing heart bypass surgery. Propofol is an...
Eligibility Criteria
Inclusion
- Patients (male and female) aged 18 years and above
- Written informed consent to participate
- Patients undergoing Coronary Artery Bypass Graft (CABG) surgery on Cardiopulmonary bypass (CPB) with or without valve surgery
- Additive European System for Cardiac Operative Risk Evaluation (EuroSCORE) of 5 or higher
Exclusion
- Pregnant or lactating women
- Allergy to propofol
- Previous diagnosis or suspected malignant hyperthermia
- Patients with a known sensitivity to any of the IMPs or other halogenated anaesthetics
- Concomitant therapy with glibenclamide or nicorandil (medications that may interfere with preconditioning)
- Inclusion in another clinical trial of an investigational medicinal product within the last 3 months.
Key Trial Info
Start Date :
November 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2022
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04039854
Start Date
November 20 2019
End Date
January 31 2022
Last Update
February 24 2021
Active Locations (2)
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1
St Thomas' Hospital
London, United Kingdom, SE1 7EH
2
Kings College Hospital NHS Foundation Trust
London, United Kingdom, SE5 9RS