Status:
COMPLETED
Personalized Recommendations for Acute Kidney Injury (AKI) Care
Lead Sponsor:
Yale University
Collaborating Sponsors:
Johns Hopkins University
Conditions:
Acute Kidney Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a randomized clinical trial of a "Kidney Action Team", which will provide timely, personalized recommendations for the diagnosis and initial treatment of hospitalized patients with Acute Kidne...
Detailed Description
Acute Kidney Injury (AKI), defined as an abrupt loss in kidney function, is common, occurring in 5-20% of hospitalized patients, and carries a significant and independent risk of inpatient mortality. ...
Eligibility Criteria
Inclusion
- Adults ≥ 18 years admitted to a participating hospital (six hospitals in the Yale New Haven Health system and two hospitals of the John Hopkins University Health system)
- Stage 1 Acute Kidney Injury as defined by KDIGO creatinine criteria:
- 3 mg/dl increase in inpatient serum creatine over 48 hours OR
- 50% relative increase in inpatient serum creatinine over 168 hours
Exclusion
- Admission to hospice service or comfort measures only order
- Recipient of a solid organ transplant
- Immediate dialytic indication determined by the following:
- serum K \>/= 7
- arterial pH \< 7.15
- BUN \> 150 mg/dL
- acute ingestion of dialyzable toxins
- refractory volume overload
- Patients who meet any of these critical values will not be enrolled in the trial and the Kidney Action Team will directly notify the treating team.
- Pre-existing CKD stage V or End Stage Kidney Disease
- Initial hospital creatinine \> 4.0 mg/dl
- Patients who have been seen by nephrology or already have a nephrology consult
- Status post-nephrectomy (partial or radical) during index admission
Key Trial Info
Start Date :
October 29 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 22 2024
Estimated Enrollment :
4003 Patients enrolled
Trial Details
Trial ID
NCT04040296
Start Date
October 29 2021
End Date
February 22 2024
Last Update
July 17 2025
Active Locations (1)
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1
Yale New Haven Hospital
New Haven, Connecticut, United States, 06510