Status:
COMPLETED
'Understanding the Electrophysiological Substrate Underlying Persistent Atrial Fibrillation Study II (USURP AF- Study II)'
Lead Sponsor:
University of Leicester
Conditions:
Atrial Fibrillation Mechanisms
Persistent Atrial Fibrillation
Eligibility:
All Genders
18+ years
Brief Summary
Atrial fibrillation (AF) is the most common type of chronic heart rhythm disease worldwide, with significant associated co-morbidities. Although there have been advances in understanding the mechanism...
Detailed Description
There are an estimated 1.4 million people in the UK with atrial fibrillation (AF), which accounts for 2.4% of the adult population.1 It is well established that AF is a major causative factor for isch...
Eligibility Criteria
Inclusion
- Must be aged 18 years or over
- Must be able to communicate in written and spoken English
- Must be able to give signed informed consent.
- All patients must be defined as having persistent atrial fibrillation (AF \> 7 days) and must be in AF at the start of the procedure.
- The patient preferably should be undergoing AF ablation for the first time, however repeat ablations can be permitted.
- The patient must be listed for persistent AF ablation as part of standard clinical care.
Exclusion
- Symptoms secondary to ischaemic or valvular heart disease
- Congenital heart disease
- Previous history of a cardiac arrhythmia (other than AF, atrial tachycardia, atrial flutter).
- Previous cardiothoracic surgery
- Underlying severe respiratory disease (i.e. patient on long term oxygen therapy)
- Medical conditions which will affect cardiac rhythm, even if treated (e.g. thyroxine, etc.)
- Presence of chest deformity.
- Left atrial dilatation (L or R atrial end-diastolic dimension \> 4.5cm in any conventional plane of measurement on 2D transthoracic echocardiography).
- Presence of implantable cardiac defibrillator or pacemaker (including cardiac resynchronisation devices).
Key Trial Info
Start Date :
July 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 30 2024
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT04041778
Start Date
July 25 2019
End Date
September 30 2024
Last Update
October 1 2025
Active Locations (1)
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1
University Hospitals Leicester NHS Foundation Trust, Glenfield Hospital
Leicester, United Kingdom, LE3 9QP