Status:
COMPLETED
Generation of Biological Samples Positive to Somatropin for Anti-doping Control
Lead Sponsor:
Parc de Salut Mar
Conditions:
Healthy Volunteers
Eligibility:
MALE
20-30 years
Phase:
PHASE1
Brief Summary
Background: Somatropin, also known as recombinant growth hormone (rhGH), is one of the World Anti-Doping Agency (WADA) prohibited substances. Its consumption in athletes has been banned since 1990, a...
Detailed Description
A blood sample volume of 450 mL is obtained from each subject receiving the treatment condition to perform the proposed tests. In order to validate the determination methodology of hGH variants and b...
Eligibility Criteria
Inclusion
- Male volunteers between 20 and 30 years old.
- History and physical examination that demonstrate not presenting organic or psychiatric disorders.
- ECG, blood and urine tests performed before the trial within normal limits. Minor or punctual variations of these limits will be allowed if, in the opinion of the principal investigator, they have no clinical significance, do not pose a risk to the subject and do not interfere in the evaluation of the product. These variations and their non-relevance will be justified in writing.
- Body mass index \[BMI: weight/height\^2\] between 19 and 26, and weight between 50 and 90 kg.
- Able to understand and accept the trial procedures and sign an informed consent.
Exclusion
- Failure to meet the inclusion criteria.
- Having suffered some organic disease or major surgery during the three months prior to the trial.
- Suffering any type of illness, acute or chronic at the time of the study.
- Background or clinical evidence of cardiovascular, respiratory, renal, hepatic, endocrine, gastrointestinal, hematological, neurological, dermatological, or other acute or chronic diseases that, in the opinion of the Principal Investigator or the collaborators designated by it, may pose a risk for the subjects, may interfere with the objectives of the study, or may suggest an alteration in the absorption, distribution, metabolism or excretion of the drug.
- Having suffered some kind of bone or ligament injury in the last three years.
- History or clinical evidence of psychiatric disorders, alcoholism, drug abuse or addiction to other substances (except for nicotine) or regular consumption of psychoactive drugs. With regard to nicotine, consumers of more than 10 cigarettes/day will be excluded.
- Alcohol consumption over 15 g/day in men and 10 g/day in women.
- Consumers of more than 3 cups of coffee and/or tea per day, consumers of more than 3 units of cola, other stimulant drinks or equivalent per day, in the 2 months prior to the start of the study.
- Regular intake of medication in the month preceding the study. Other kinds of medication may be admitted at the discretion of the Investigator.
- Having donated blood or participated in studies in which there were blood draws in the previous 4 weeks.
- History of allergy, idiosyncrasy, hypersensitivity or adverse reactions to the active principle or any of the excipients. Serious adverse drug reactions.
- Having participated in another clinical trial with medication in the three months prior to the start of the study.
- Subjects with contraindications to treatment with the study drug (according to the summary of product characteristics).
- Positive serology to hepatitis B, C or HIV.
- Being unable to understand the nature, consequences of the trial and the procedures that are asked to follow.
Key Trial Info
Start Date :
October 25 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 8 2020
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT04042428
Start Date
October 25 2019
End Date
January 8 2020
Last Update
February 12 2020
Active Locations (1)
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1
IMIM (Hospital del Mar Medical Research Institute)
Barcelona, Spain, 08003