Status:
TERMINATED
The Effects of Renal Function and Atrial Fibrillation on Lipoproteins and Clot Structure/Function
Lead Sponsor:
University of Liverpool
Collaborating Sponsors:
Liverpool Centre for Cardiovascular Science
Liverpool Heart and Chest Hospital NHS Foundation Trust
Conditions:
Atrial Fibrillation
Chronic Kidney Disease
Eligibility:
All Genders
18+ years
Brief Summary
This study is designed to investigate the role of lipids/lipoproteins as a potential cause for the harmful changes seen in fibrin clot properties with renal dysfunction and atrial fibrillation
Detailed Description
This is a prospective, observational, blinded study that will be conducted in two parts. The first study will assess the relationship between lipids/lipoproteins and fibrin clot properties among antic...
Eligibility Criteria
Inclusion
- 1 Inclusion criteria
- WP1:
- On anticoagulation therapy
- Informed consent obtained
- WP2:
- Not receiving statins prior to recruitment
- Diagnosed atrial fibrillation
- On anticoagulation therapy
- Estimated glomerular filtration rate of \<50 ml/min/1.73m2
- Informed consent obtained
- 2 Exclusion criteria
- Age \<18 years
- Severe mitral stenosis or presence of metallic prosthetic valve
- Active or recent malignancy (\<6 months)
- Active immunological disease
- Connective tissue disease
- Chronic liver disease
- Recent or chronic serious infection
- Chronic inflammatory disease
- Known haemophilia or thrombophilia
- Active bleeding
- Untreated hypothyroidism or hyperthyroidism
- Recent surgery (\<3 months)
- Familial lipid disorders
- Concurrent use of steroids
- Dietary supplements known to influence lipids
- Contraindications/inability/unwillingness to commence statin (WP2)
Exclusion
Key Trial Info
Start Date :
September 26 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2022
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT04043026
Start Date
September 26 2019
End Date
August 1 2022
Last Update
August 8 2022
Active Locations (2)
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1
Liverpool Heart and Chest Hospital
Liverpool, United Kingdom
2
Liverpool University Hospitals NHS Foundation Trust
Liverpool, United Kingdom