Status:
COMPLETED
Effects of High-intensity Noninvasive Positive Pressure Ventilation in AECOPD
Lead Sponsor:
Beijing Chao Yang Hospital
Conditions:
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study aims to investigate the effects of high-intensity noninvasive positive pressure ventilation (NPPV), as compared with low-intensity NPPV, on hypercapnia, consciousness, inspiratory muscle ef...
Eligibility Criteria
Inclusion
- Diagnosis of COPD according to the criteria of the Global Initiative for Chronic Obstructive Lung Disease in 2019
- Presence of acute exacerbation
- Arterial pH \<7.35 with arterial carbon dioxide tension (PaCO2) \>45 mmHg on room air or supplemental oxygen
- PaCO2 \>45 mmHg following low-intensity NPPV of ≥6 hours
Exclusion
- Age \<18 years
- Excessive amount of respiratory secretions or weak cough
- Upper airway obstruction
- Recent oral, facial, or cranial trauma or surgery; recent gastric or esophageal surgery
- Potential risk factors for restrictive ventilatory dysfunction (eg, consolidation or removal of at least one pulmonary lobe, massive pleural effusion, chest wall deformity, continuous strapping with thoracic or abdominal bandage, and severe abdominal distention)
- Active upper gastrointestinal bleeding
- Cardiac or respiratory arrest
- Arterial oxygen tension/fraction of inspired oxygen \<100 mmHg
- Pneumothorax
- Severe ventricular arrhythmia or myocardial ischemia
- Severe hemodynamic instability despite fluid repletion and use of vasoactive agents
- Severe metabolic acidosis
- Refusal to receive NPPV
- Endotracheal intubation already performed before ICU admission
Key Trial Info
Start Date :
September 30 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 16 2021
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04044625
Start Date
September 30 2019
End Date
June 16 2021
Last Update
May 10 2022
Active Locations (1)
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1
Beijing Chao-Yang Hospital
Beijing, China