Status:
UNKNOWN
Intensity of Aerobic Training and Neuroprotection in Parkinson's Disease
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Parkinson's Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
In phenotypic animal models of Parkinson's Disease (PD), chronic physical exercise has produced nigrostriatal neuroprotection and symptom improvement, provided training was of high-intensity and prolo...
Detailed Description
A short description, 5000 characters Intro: In phenotypic animal models of Parkinson's Disease (PD), chronic physical exercise has produced nigrostriatal neuroprotection and symptom improvement, provi...
Eligibility Criteria
Inclusion
- Diagnosis of PD according to the UKPDSBB criteria
- Previous MRI available, to further help distinguish idiopathic PD from atypical parkinsonism Hoehn \& Yahr Stage 1-3 in OFF state
- Age \> 18
- Signed informed consent to participate in study
Exclusion
- Patients lacking motivation or ability to participate in training sessions for 9 months, in the investigator's opinion
- Contra-indications to high-intensity aerobic training in the cardiologist's opinion
- Contra-indications to perchlorate de potassium or to the use of 123I-FP-CIT
- Concurrent severe co-morbidities
- Cognitive deficit limiting participation to the program in the investigator's opinion
- Montreal Cognitive Assessment test (MoCA)\<23
- Uninsured patient
- Participation in another ongoing interventional clinical trial (drug therapy, surgical treatment, another rehabilitation treatment, medical device)
- Pregnancy or current lactation, or no efficacious contraception during the 9 months of intervention.
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2021
Estimated Enrollment :
69 Patients enrolled
Trial Details
Trial ID
NCT04046276
Start Date
September 1 2019
End Date
November 1 2021
Last Update
August 6 2019
Active Locations (3)
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1
Henri Mondor Hospital
Créteil, France, 94010
2
Sébastopol hospital
Reims, France, 51100
3
Rangueil hospital
Toulouse, France, 31059