Status:
RECRUITING
Genetic Causes of Discrepant Clinic in Monogenic Twins
Lead Sponsor:
University Hospital Tuebingen
Conditions:
Rare Diseases
Genetic Predisposition to Disease
Eligibility:
All Genders
Brief Summary
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics te...
Eligibility Criteria
Inclusion
- Twin pair monozygotic clinically (phenotypic) discordant twins
- Unclear diagnosis
- Suspected (mono-)genetic cause of the disease in one twin
Exclusion
- Missing informed consent of both twin/ legal representative
- No distinct phenotype
Key Trial Info
Start Date :
December 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04046796
Start Date
December 1 2019
End Date
December 1 2027
Last Update
March 30 2025
Active Locations (1)
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1
University Hospital Tübingen
Tübingen, Germany, 72076