Status:
COMPLETED
Efficacy and Safety of Oral Anticoagulants Among Thai Octogenarians With Nonvalvular Atrial Fibrillation
Lead Sponsor:
Mahidol University
Conditions:
Stroke
Atrial Fibrillation
Eligibility:
All Genders
80+ years
Brief Summary
A retrospective cohort study of Thai octogenarians with nonvalvular atrial fibrillation (NVAF) initiating apixaban, dabigatran, rivaroxaban or warfarin was conducted in medical school hospital in Thai...
Detailed Description
This is a retrospective cohort study of Thai octogenarians with NVAF. Patients who were prescribed with apixaban, dabigatran, edoxaban, rivaroxaban or warfarin from January 1, 2013, to December 31, 20...
Eligibility Criteria
Inclusion
- Age more than 80 years old
- Patients who were diagnosed with I48, I63 or G45 from International Classification of Diseases 10th version (ICD-10). Patients who were diagnosed atrial fibrillation and flutter, cerebral infarction or transient cerebral ischemic attacks (TIA) and related syndromes)
- Patients were prescribed apixaban, dabigatran, edoxaban, rivaroxaban, or warfarin
Exclusion
- Patients were prescribed oral anticoagulants for other indications
- Prophylaxis thromboembolic events in valvular atrial fibrillation
- Treatment of venous thromboembolism
- Prophylaxis thromboembolic events in hip or knee replacement
- Patients who had contraindication to oral anticoagulants
- Creatinine clearance calculated from Cockcroft-Gault equation 1.1 Creatinine clearance less than 30 mL/min (for patients who receiving Dabigatran) 1.2 Creatinine clearance less than 15 (mL/min (for patients who receiving Apixaban, Edoxaban, Rivaroxaban)
- Patients were diagnosed acute hepatitis, chronic active hepatitis
Key Trial Info
Start Date :
April 22 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
327 Patients enrolled
Trial Details
Trial ID
NCT04047654
Start Date
April 22 2019
End Date
December 31 2019
Last Update
February 21 2020
Active Locations (1)
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1
Siriraj Hospital, Phramongkutklao Hospital
Bangkok, Thailand, 10700