Status:
COMPLETED
Cytokine Removal With CVVHD Compared to CVVH
Lead Sponsor:
Hospital Universitari de Bellvitge
Collaborating Sponsors:
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Conditions:
Cytokine Release Syndrome
Sepsis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Septic patients with acute kidney injury (SA-AKI) requiring continuous renal replacement therapies (CRRT) present high mortality due to systemic inflammatory response, cytokine liberation, and finally...
Detailed Description
Investigators will warrant a correct protocol application. Study data will be reviewed by an external monitoring committee from the clinical assay research central unit (UCICEC - IDIBELL). Monitors wi...
Eligibility Criteria
Inclusion
- Less than 72 hours from ICU admission to inclusion
- Clinical diagnosis of Severe Sepsis or Septic shock (SCCM definitions)
- Correct therapeutic initial management of septic process (SSC guidelines)
- Clinical diagnosis of Acute Kidney Injury (ADQI definitions)
- Acute Kidney Injury meeting CRRT initiation criteria (ADQI guidelines)
- Written informed consent from patient or legal surrogates
Exclusion
- End Stage Renal Disease(ESRD)
- Received previous CRRT or hemodialysis in the last three months
- Inclusion in other ongoing study
- Coexisting illness with a high probability of death
Key Trial Info
Start Date :
March 13 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2016
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04048525
Start Date
March 13 2013
End Date
March 1 2016
Last Update
March 5 2020
Active Locations (2)
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1
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain, 08907
2
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain