Status:
UNKNOWN
Search for Biomarkers of Neurodegenerative Diseases in Idiopathic REM Sleep Behavior Disorder
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
REM Sleep Behavior Disorder
Neurodegeneration
Eligibility:
All Genders
50+ years
Brief Summary
This study is a prospective study with a mean of 7-year follow-up interval, aims to monitor the progression of α-synucleinopathy neurodegeneration by the evolution of prodromal markers and development...
Detailed Description
REM sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behaviors and REM sleep without muscle atonia (excessive EMG activity) during REM sleep.Increasing studies revealed t...
Eligibility Criteria
Inclusion
- for iRBD at baseline:
- Fulfilling the diagnostic criteria for iRBD. As patients with iRBD were recruited during a long period, the diagnosis of RBD was based on ICSD and ICSD-2 (before 2014), and ICSD-3 (2014 and thereafter) criteria. The diagnosis for all patients were confirmed by video-PSG. In summary, patient diagnosed with RBD should present excessive EMG activity during REM sleep on video-PSG assessment and report a history of repeated dream enactment behaviors;
- Having neurocognitive test and neurological examination since 2008;
- Free of neurodegenerative diseases at the last visit.
- for controls without iRBD at baseline:
- Age- and sex- matched with patients with iRBD;
- Free of narcolepsy and other neurological diseases;
- Without any RBD features as confirmed by both clinical history and video-PSG;
- Without neurodegenerative diseases;
- Having neurocognitive test and neurological examination at baseline.
Exclusion
- Patients with narcolepsy;
- Patients with known neurodegenerative diseases;
- Pseudo-RBD (e.g., RBD symptoms were eliminated after severe obstructive sleep apnea had treated with continuous positive airway pressure therapy.);
- Early-onset RBD (e.g., before the age of 50 years old) which might have a different pathogenesis from iRBD.
Key Trial Info
Start Date :
May 15 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
October 1 2022
Estimated Enrollment :
182 Patients enrolled
Trial Details
Trial ID
NCT04048603
Start Date
May 15 2019
End Date
October 1 2022
Last Update
August 6 2021
Active Locations (1)
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1
Department of psychiatry, Faculty of Medicine, The Chinese University of Hong Kong
Hong Kong, Hong Kong