Status:
COMPLETED
Prospective Study for the Evaluation of Dengue Prognostic Biomarkers in Singapore
Lead Sponsor:
National University Hospital, Singapore
Collaborating Sponsors:
Tan Tock Seng Hospital
Ng Teng Fong General Hospital
Conditions:
Dengue Hemorrhagic Fever
Dengue Shock Syndrome
Eligibility:
All Genders
21-100 years
Brief Summary
World Health Organisation (WHO) has identified Dengue as the fastest spreading mosquito-borne disease in the world. This study follows on from the National Medical Research Council STOP Dengue Transla...
Detailed Description
This is a non-interventional, prospective study aim to recruit 200 subjects from National University Hospital, Tan Tock Seng Hospital and Ng Teng Feng General Hospital over a period of 2 years to dete...
Eligibility Criteria
Inclusion
- Confirmed Dengue i.e. laboratory confirmation of acute Dengue for this current disease episode by either (i) Positive polymerase chain reaction (PCR) for viral ribonucleic acid (RNA), or (ii) Positive NS1 antigen test with a compatible clinical syndrome
- At least 21 years of age based on his/her birthday, and
- Willing and able to give informed consent.
Exclusion
- Already classified as having Dengue Haemorrhagic Fever or Dengue Shock Syndrome (WHO 1997 classification) or severe Dengue (WHO 2009 classification) when they first present themselves to the hospital.
- Assessed by Investigators to be unlikely to comply with trial procedures.
- Have known or suspected congenital or acquired immunodeficiency, immunosuppressive therapy such as anti-cancer chemotherapy or radiation therapy within the past 6 months or long term corticosteroid therapy.
- Have received blood or blood-derived products in the past three months that might interfere with the assessment of the biomarker responses.
- Have participated in another clinical trial investigating a vaccine or drug in the four weeks preceding the study.
- Have received any vaccine in the four weeks preceding the study.
- Are deprived of freedom by an administrative or court order or in an emergency setting or hospitalized without his/her consent.
Key Trial Info
Start Date :
July 30 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2019
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04048837
Start Date
July 30 2018
End Date
July 1 2019
Last Update
September 13 2019
Active Locations (3)
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1
Tan Tock Seng Hospital
Singapore, Singapore, 308433
2
Ng Teng Fong General Hospital
Singapore, Singapore, 609606
3
National University Hospital
Singapore, Singapore