Status:
COMPLETED
Biomarkers in Urine for Children With Monosymptomatic Nocturnal Enuresis and Nocturnal Polyuria
Lead Sponsor:
University of Aarhus
Conditions:
Nocturnal Enuresis
Eligibility:
MALE
6-14 years
Phase:
NA
Brief Summary
The aim of the study is to identify protein markers in relation to the enuresis related nocturnal polyuria by using mass spectrometry on nocturnal urine samples. A biomarker for nocturnal polyuria wou...
Detailed Description
Involuntary voiding during sleep, nocturnal enuresis (NE), affects 7-10 % of all 7-year-olds, and 0.5-2 % of young adults. Night-time polyuria is one of the main pathogenic mechanisms. Today, the only...
Eligibility Criteria
Inclusion
- Monosymptomatic nocturnal enuresis with at least one dry night per week.
- Nocturnal polyuria defined as nocturnal urine production on wet nights greater than 130 % of expected bladder capacity for age.
- Normal bladder capacity defined as maximum voided volume excluding first morning voided volume bigger than expected bladder capacity for age.
Exclusion
- Recurrent urinary tract infections.
- Anamnestic, clinical or laboratory findings that can be related to diseases or conditions that might affect the parameters investigated.
- Neurological and/or known clinically significant anatomical abnormalities of the urinary tract.
- Former operations in the urinary tract.
- Ongoing medication that may interfere with the parameters tested.
- If the child is receiving treatment for nocturnal enuresis (desmopressin, alarm or anticholinergics), the treatment has to be paused 1 week before urine collection.
- Furthermore, we will include 10 children without nocturnal enuresis and otherwise healthy.
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04049019
Start Date
August 1 2019
End Date
September 1 2022
Last Update
July 7 2023
Active Locations (1)
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1
Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital
Aarhus, Jylland, Denmark, 8200