Status:
ACTIVE_NOT_RECRUITING
Dietary Oxalate and Innate Immunity in Kidney Stone Disease
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Kidney Stone
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
This study will test whether oxalate stimulates urinary crystals and impacts the immune system in healthy subjects using two controlled diets (low and high oxalate).
Detailed Description
Oxalate is a small molecule found in plants and plant-derived food. It has been shown that meals containing high amounts of oxalate can increase urinary oxalate excretion, which is a risk factor for c...
Eligibility Criteria
Inclusion
- Healthy subjects (men and women) between the ages of 18 and 60 years of age
- No calcium oxalate kidney stones or other medical conditions
- Normal comprehensive metabolic panel (CMP)
- Non tobacco users
- Not pregnant
- BMI between 20-30 kg/m2
- Willing to abstain from vigorous exercise and vitamins/supplements during the study
- Willing to consume only provided diets, accurately collect 24-hour urine samples, and have blood drawn
Exclusion
- Inability to sign and read the informed consent
- Any medical, psychiatric, or social conditions that would prohibit participants from abiding by the study requirements
- Physician refusal
- Pregnant women
- Active medical problems
- History of kidney stones or any medical condition that could influence absorption or excretion of oxalate
- Tobacco users
- Taking medications or dietary supplements
- BMI \>30 or \<20
Key Trial Info
Start Date :
March 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04051346
Start Date
March 5 2021
End Date
May 1 2026
Last Update
May 8 2025
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233