Status:
UNKNOWN
Plasma Exchange in Acute on Chronic Liver Failure
Lead Sponsor:
Asian Institute of Gastroenterology, India
Conditions:
Cirrhosis, Liver
Acute-On-Chronic Liver Failure
Eligibility:
All Genders
18-75 years
Phase:
PHASE3
Brief Summary
Acute on chronic liver failure (ACLF) is a distinct syndrome in patients with chronic liver disease with rapid clinical deterioration and has high short term mortality within one month.Despite aggress...
Detailed Description
Acute on chronic liver failure (ACLF) lacks a consensus definition and definitive management approaches. The various management strategies include treatment of acute insult, support of multiple organ ...
Eligibility Criteria
Inclusion
- Patients diagnosed with ACLF as per APASL criteria with AARC score of ≥8
Exclusion
- Uncontrolled sepsis
- Septic shock requiring inotropes despite fluid resuscitation
- Active or recent bleeding (unless controlled for \>48 hours).
- Severe thrombocytopenia (≤20×10\^9/L)
- Acute kidney injury with Creatinine \> 2 or the need of RRT
- Respiratory failure (Severe ARDS)
- Chronic kidney disease
- Hepatocellular carcinoma outside Milan criteria (1 nodule ≤5 cm or 3 nodules ≤3 cm)
- HIV infection
- Pregnancy
Key Trial Info
Start Date :
August 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2020
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT04051437
Start Date
August 15 2019
End Date
March 31 2020
Last Update
August 9 2019
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