Status:
RECRUITING
Paradoxical Tuberculosis Reactions in Patients Without HIV Infection
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Tuberculosis
Eligibility:
All Genders
18-99 years
Brief Summary
Background: Most people with tuberculosis (TB) feel better after starting treatment. But for some people, the opposite happens. They may feel better at first, but then suddenly get worse. This is a p...
Detailed Description
Paradoxical reaction in non-HIV tuberculosis (TB) is a clinical and/or radiologic worsening of a patient s pre-existing TB while receiving anti-TB medications. This phenomenon has been clinically well...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Suspected Paradoxical Reaction Group Criteria:
- Aged greater than or equal to 18 years.
- Diagnosed with confirmed (microbiologically or with molecular methods) or suspected (clinical plus or minus histologic diagnosis) TB and currently on ATT for a minimum of 2 weeks, or have completed ATT, with at least 2 of the following signs/symptoms of a paradoxical inflammatory reaction:
- Recrudescent symptoms of TB after initial clinical improvement.
- Change in physical exam after initial clinical improvement suggestive of new inflammatory process (e.g., lymphadenopathy or new findings on pulmonary exam).
- Worsening radiographic evidence of disease after initiation of treatment, as compared with imaging prior to or earlier in treatment.
- Laboratory evidence of acute inflammatory response, including the development of leukocytosis (white blood cell count \> 10,000 cells/microL) or a change of C-reactive protein (CRP) \> 5 mg/L compared to prior laboratory values.
- Worsened organ function after initial clinical improvement.
- The above sign/symptom(s) cannot be explained by a newly acquired infection, clinical course of a previously recognized infectious agent, side effects of the ATT, the presence of drug resistance, or any other condition except for paradoxical reaction.
- Willingness to allow storage of blood or tissue samples for future research.
- Ability of participant to understand study requirements and give informed consent.
- Has a primary care physician and is being followed by the local Department of Health for their TB (or has plans to arrange after enrollment if enrolled early in course from inpatient transfer).
- Control Group Criteria:
- Aged greater than or equal to 18 years.
- Diagnosed with confirmed (microbiologically or with molecular methods) or suspected (clinical plus or minus histologic diagnosis) TB.
- Presenting 2 to 4 months after starting ATT to match timing of paradoxical reactions.
- Willingness to allow storage of blood or tissue samples for future research.
- Ability of participant to understand study requirements and give informed consent.
- Has a primary care physician and is being followed by the Department of Health for their TB (or has plans to arrange after enrollment if enrolled early in course from inpatient transfer).
- EXCLUSION CRITERIA:
- Individuals in either group who meet any of the following criteria will be excluded from study participation:
- HIV infection. (Individuals with HIV infection may be eligible for a separate study exclusively evaluating persons living with HIV.)
- Pregnant or breastfeeding.
- Uncontrolled psychiatric disease, substance use, or inappropriate conduct unsuitable for a research study.
- Malignancy requiring imminent or ongoing treatment including radiation, chemotherapy, or immunotherapy.
- Debilitating or chronic conditions that would limit ability to participate in the study.
- Emergent or urgent clinical conditions not due to studied disease of interest requiring immediate treatment that would be unsuitable for a research study. These patients would be transferred to an emergency room and able to rescreen when condition has been stabilized.
Exclusion
Key Trial Info
Start Date :
December 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2029
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04052022
Start Date
December 20 2019
End Date
April 30 2029
Last Update
December 2 2025
Active Locations (2)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
2
Mexican Emerging Infectious Diseases Clinical Research Network (LaRed)
Alcaldia Tlalpan, Mexico, 14050