Status:
TERMINATED
Progestin Priming Ovarian Stimulation (PPOS) Compared With Antagonist Protocol for Freeze-all Cycles
Lead Sponsor:
Ibn Sina Hospital
Conditions:
Infertility
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Stimulation protocols for IVF underwent several cycles of upgrading aiming to achieve reasonable outcomes with low-cost cycles. Antagonist protocols have been introduced as effective and comparable to...
Eligibility Criteria
Inclusion
- Women age of ≥ 18 to ≤ 40;
- BMI of ≤ 31;
- All indication for freeze-all
- PCOS;
- Women who have ≥ 1 year of primary or secondary infertility;
- Tubal factor (unilateral, bilateral obstruction or salpingectomy);
- Fresh ejaculate sperm of any count provided they have ≥ 1% normal forms and a motile fraction;
- Women undergoing their first ICSI cycle or following a previous successful attempt;
- Women undergoing only frozen-thawed embryo transfer;
- Women with \> 8 mm endometrial thickness at the day of progesterone supplementation in the transfer cycle;
- Women with no detected uterine abnormality on transvaginal ultrasound (e.g. submucosal myomas, polyps or septa).
Exclusion
- Unilateral oophorectomy;
- Uterine pathology or abnormality;
- Abnormal karyotyping for them or their male partners;
- History of repeated abortions or implantation failure;
- Uncontrolled diabetes;
- Liver or renal disease;
- History of malignancy or borderline pathology;
- Endometriosis;
- Plan for PGD-A;
- Severe male factor includes surgical sperm retrieval or cryopreserved sperm.
Key Trial Info
Start Date :
September 10 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 30 2020
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT04052607
Start Date
September 10 2019
End Date
April 30 2020
Last Update
June 15 2022
Active Locations (3)
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1
Banon Fertility Center
Asyut, Egypt
2
IbnSina IVF Center, IbnSina Hospital
Sohag, Egypt, 12345
3
AlRahma Hospital
Sohag, Egypt