Status:
WITHDRAWN
Lipodystrophy and Fat Metabolism During Exercise
Lead Sponsor:
University of Exeter
Conditions:
Healthy
Lipodystrophy, Familial Partial
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
Mandibular dysplasia with deafness and progeroid features (MDP) syndrome is a rare genetic metabolic disorder that causes lipodystrophy: the inability of the body to store subcutaneous adipose tissue ...
Detailed Description
During prolonged sub-maximal endurance exercise, both fat and carbohydrate are readily used substrates. The relative contribution and regulation of either is dependent on substrate availability (endog...
Eligibility Criteria
Inclusion
- SUBJECT WITH FPL
- Inclusion:
- • Already known to researchers. Male, 29 years old.
- CONTROL SUBJECT 1
- Inclusion:
- Highly trained, elite-level cyclist (VO2max \> 80 ml/kg/min)
- Registered with, and racing under the jurisdiction of, British Cycling
- \~\< 10% of body fat
- Male
- 18 - 35 years old
- Exclusion:
- Any diagnosed metabolic impairment, as this may affect normal metabolism.
- Any diagnosed cardiovascular disease or hypertension to avoid any complications associated with heavy exercise.
- Chronic use of any prescribed or over-the-counter pharmaceuticals.
- CONTROL SUBJECT 2
- Inclusion:
- Recreationally active, preferably with experience of cycling training.
- Similar (± 5 ml⋅kg-1⋅min-1) VO2max¬ to that of the participant with MDP
- Exclusion:
- Any diagnosed metabolic impairment, as this may affect normal metabolism.
- Any diagnosed cardiovascular disease or hypertension to avoid any complications associated with heavy exercise.
- Chronic use of any prescribed or over-the-counter pharmaceuticals.
- SUBJECT WITH FPL
- Inclusion:
- Recreationally active, preferably with experience of cycling training.
- Similar (± 5 ml⋅kg-1⋅min-1) VO2max¬ to that of the participant with MDP
- Diagnosis with FPL
- Exclusion:
- Female
- Any diagnosed cardiovascular disease or hypertension to avoid any complications associated with heavy exercise.
Exclusion
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04056000
Start Date
September 1 2019
End Date
December 31 2019
Last Update
August 31 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
School of Sport and Health Sciences
Exeter, Devon, United Kingdom, EX4 4JA