Status:
COMPLETED
Gastro-intestinal and Hormonal Responses to Systemic Inflammatory Disease
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Arla Food Ingrediens
Aarhus University Hospital
Conditions:
Motility Disorder
Catabolic State
Eligibility:
MALE
20-40 years
Phase:
NA
Brief Summary
The aim of this study is to describe hormonal responses and changes of the gastrointestinal (GI) tract during healthy and catabolic inflammatory conditions. Participants will receive isocaloric, ison...
Detailed Description
Background: Endotoxemia (LPS) is known to cause fever, inflammation and nausea, but the underlying mechanisms are unknown. In a human disease model comprising LPS-induced inflammation, 36 hour fast an...
Eligibility Criteria
Inclusion
- Between 20-40 years of age
- Body mass index between 20-30 kg/m\^2
- Healthy
- Oral and written consent forms obtained prior to study day
Exclusion
- Recent immobilization of an extremity that is not fully rehabilitated
- Lactose, lidocain or rubber allergies
- Current disease
- Use of anabolic steroids
- Smoking Former major abdominal surgery (Or current problems with the GI tract) \>10 hours of exercise/weak Present ketogenic diets or high-protein diets Blood doner that does not want to discontinue blood donations until study completion Pending MR scan
Key Trial Info
Start Date :
June 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 23 2020
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT04056286
Start Date
June 17 2019
End Date
January 23 2020
Last Update
June 11 2020
Active Locations (1)
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1
Medical Reasearch labaratory, DoH, Aarhus University Hospital
Aarhus N, Danmark, Denmark, 8200