Status:
UNKNOWN
Acute Effect of modeRate-intensity aerOBIc Exercise on Colon Cancer Cell Growth
Lead Sponsor:
Northumbria University
Collaborating Sponsors:
York St John University
Newcastle University
Conditions:
Colon Adenocarcinoma
Colon Cancer
Eligibility:
MALE
50-90 years
Phase:
NA
Brief Summary
This study involves drawing blood samples from men before and after they perform 30-minutes of moderate-intensity aerobic exercise. The investigators will evaluate whether adding the exercise serum to...
Detailed Description
Regular exercise is associated with a reduced risk of developing colon cancer. However, the mechanisms underpinning the anti-cancer effect of exercise are not yet fully understood. A recent theory sug...
Eligibility Criteria
Inclusion
- Age ≥ 50 years
- BMI ≥ 25 kg/m2 and/or waist circumference of ≥ 94 cm
- Male
- Participating in less than 30 min of planned, structured, moderate to vigorous-intensity physical activity on three or more d·wk-1 for the last three months
Exclusion
- Any absolute or relative contraindication to exercise testing, as determined by the American College of Sports Medicine
- Any sign/symptom of cardiovascular, metabolic or renal disease
- Known cardiovascular, metabolic or renal disease without written medical clearance from physician
- Resting hypertension (≥160 mmHg systolic and/or ≥90 mmHg diastolic)
- Chronic obstructive pulmonary disease and/or asthma with peak respiratory flow \< 300 l/min
- Previous stroke or transient ischemic attack
- Epilepsy or aneurysm (large vessel or cerebral)
- Previous or current treatment for malignancy
- Clotting disorder
- Taking beta-adrenergic blocking agents
- Resting heart rate ≥ 100 bpm
- Musculoskeletal, neurological, anthropometric, or rheumatoid conditions that makes it not possible to pedal a bicycle and/or would be worsened due to exercise
- Body mass \> 150 kg
Key Trial Info
Start Date :
September 23 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2020
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT04057274
Start Date
September 23 2019
End Date
September 30 2020
Last Update
August 20 2020
Active Locations (2)
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1
York St John University Sports Park
York, North Yorkshire, United Kingdom, YO31 8FY
2
Northumbria University City Campus
Newcastle upon Tyne, United Kingdom, NE1 8SG