Status:
COMPLETED
A Study of MHE in Patients With Liver Diseases
Lead Sponsor:
Qin Ning
Conditions:
Hepatic Encephalopathy
Minimal Hepatic Encephalopathy
Eligibility:
All Genders
18+ years
Brief Summary
The study analyzes the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predicts risk factors on the development of OHE and investigate the mortality of MHE in patients wit...
Detailed Description
Hepatic encephalopathy (HE) is a common complication and one of the most serious manifestations of cirrhosis and acute on chronic liver failure, not only increasing the risks of death, but also seriou...
Eligibility Criteria
Inclusion
- \>18 years old
- cirrhosis
- acute on chronic liver failure
Exclusion
- (1) status of OHE; (2) accompanying nervous system diseases, such as dementia or stroke; (3) a history of recent head trauma or surgery, and (4) organic lesions in the brain, such as haemorrhages or infarction; (5) inability to finish the psychometric hepatic encephalopathy score (PHES), such as unable to observe patterns or words clearly on paper, and (6) a recent transjugular intrahepatic portosystemic shunt (TIPS) or abdominal imaging demonstrated portosystemic shunts, and (7) high alcohol consumption (\> 30 g/day in men or 20 g/day in women) or psychoactive medication consumption in the past four weeks.
Key Trial Info
Start Date :
May 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2022
Estimated Enrollment :
252 Patients enrolled
Trial Details
Trial ID
NCT04058327
Start Date
May 1 2019
End Date
December 30 2022
Last Update
June 17 2024
Active Locations (1)
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1
Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China