Status:
ACTIVE_NOT_RECRUITING
nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Metastatic Malignant Neoplasm in the Brain
Radiation Therapy Recipient
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This trial studies how well nTMS works in planning for stereotactic radiosurgery in patients with brain metastases in the motor cortex. Stereotactic radiosurgery is a type of radiation therapy that de...
Detailed Description
PRIMARY OBJECTIVES: I. To determine if the use of navigated transcranial magnetic stimulation (nTMS) in the radiation oncology clinic is feasible. SECONDARY OBJECTIVES: I. To investigate the relati...
Eligibility Criteria
Inclusion
- Adult patients with brain metastases located in or near the motor cortex who have previously received SRS to that lesion within the prior 3-18 months
- Patients must be able to participate in nTMS of bilateral motor cortices
- Patients must be able to participate in an electromyography (EMG)
- Patient's must have utilized magnetic resonance imaging (MRI) for their previous SRS treatment planning
- Patient must be able to complete the Functional and Quality of Life questionnaires in English
Exclusion
- Significant cognitive or psychiatric symptoms that prevent the ability to complete a physical exam, questionnaires, or participate in nTMS or EMG
- Poor performance status Karnofsky performance score (KPS \< 60) that prevents the ability to participate in a physical exam, nTMS, or EMG. Patients will not be excluded if they are not able to complete the exploratory EEG analysis
- Patients receiving any prior treatment that might impact their cognitive, psychiatric, or motor cortex function
Key Trial Info
Start Date :
September 9 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 6 2027
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT04062305
Start Date
September 9 2019
End Date
May 6 2027
Last Update
July 28 2025
Active Locations (1)
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1
M D Anderson Cancer Center
Houston, Texas, United States, 77030