Status:
COMPLETED
Autonomic Nervous System and Sickle Cell Disease
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Heart Rate Variability (ANS Function)
Eligibility:
All Genders
6-16 years
Brief Summary
Sickle cell disease (SCD) children and adults with asthma have an increased rate of vaso-occlusive crisis, acute chest syndrome episodes, and premature mortality when compared to those without asthma....
Detailed Description
Heart rate variability during pulmonary function tests (spirometry, static volumes, DLCO/DLNO, exhaled NO at multiple flow rates) including salbutamol administration will be evaluated in patients with...
Eligibility Criteria
Inclusion
- age from 8 to 16 years (≥ 8 years and \< 16 years) (spirometry and DLCO study feasible)
- Sub-Saharan African or Caribbean ethnic origin.
- child with sickle cell disease referred for monitoring of respiratory function in the framework of its sickle cell disease and whether or not it presents a possible disease asthmatic (asthma treatment prescribed in the past year)
- or asthmatic child (typical functional signs + history of exacerbation severe hospitalized or reversible obstructive pulmonary disorder) not sickle cell
- addressed for respiratory function monitoring
Exclusion
- Refusal to participate (lack of consent)
- Sickle cell child of North African origin
Key Trial Info
Start Date :
January 5 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2019
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT04062409
Start Date
January 5 2018
End Date
May 31 2019
Last Update
February 3 2023
Active Locations (1)
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1
Robert Debre Hospital
Paris, France, 75019