Status:
UNKNOWN
Epigenetics and Gut Microbiota in Children With Epilepsy
Lead Sponsor:
Oslo University Hospital
Collaborating Sponsors:
Norwegian University of Life Sciences
University of Oslo
Conditions:
Epilepsy
Eligibility:
All Genders
2-17 years
Phase:
NA
Brief Summary
The ketogenic diet is a high-fat, low-carbohydrate diet used in the treatment of epilepsy. The diet can be an efficient treatment option in children with drug resistant epilepsy, with more than 50 % s...
Detailed Description
The ketogenic diet is a high-fat, moderate protein, low-carbohydrate diet. It is an internationally established treatment option in children with drug resistant epilepsy. About 40 -70 % of children wi...
Eligibility Criteria
Inclusion
- Drug resistant epilepsy
- Age 2- 17 years
- Two or more countable seizures/week
- Willing to try treatment with the ketogenic diet for at least 12 weeks
Exclusion
- Glucose transporter protein 1 deficiency, pyruvate dehydrogenase deficiency, or pyruvate carboxylase deficiency
- Known or suspected disease in wich the diet is contraindicated
- Epilepsy surgery the last 6 months before diet initiation
- Steroid medications the last 2 months before diet initiation
- Breastfeeding
- Psychogenic non-epileptic seizures
- Eating disorder
- Pregnancy or planed pregnancy
- Feeding disabilities not compatible with dietary treatment
- Inability to follow study scheme
- Previous treatment with high-fat, low- carbohydrate diet
- Medical need to start dietary treatment immediately
Key Trial Info
Start Date :
August 15 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04063007
Start Date
August 15 2017
End Date
November 1 2022
Last Update
September 22 2022
Active Locations (1)
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1
Oslo University Hospital
Oslo, Norway, 0424