Status:
COMPLETED
Parameters of Exercise to Prevent Osteoporosis
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
University of Wisconsin, La Crosse
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Osteoporosis, Postmenopausal
Eligibility:
FEMALE
50-65 years
Phase:
NA
Brief Summary
The principal goal of this study is to determine parameters of walking in terms of peak mechanical vertical force, bout duration, and bout spacing that can preserve or increase bone mineral density (B...
Detailed Description
A. Hypotheses and specific aims: Specific aim 1. Measure plasma concentrations of anabolic hormones (parathyroid hormone (PTH) and growth hormone (GH), at sufficient frequency to define the area unde...
Eligibility Criteria
Inclusion
- Age 50 to 65 years if naturally post-menopausal, or age 47 if surgically postmenopausal
- Dual energy X-ray absorptiometry (DEXA) Z score above -1
- No endocrine or metabolic disease requiring medication except for hormonally corrected hypothyroidism
- No musculo-skeletal disabilities that would preclude treadmill walking
- Normal electrocardiogram (EKG) and heart health history
- BMI between 24 and 30
- Hematocrit above 32 %
- No hormone replacement therapy (HRT)
- Personal health provider's Release Letter
Exclusion
- Age and BMI outside of the specified range
- Z score below -1
- Medication for presence of metabolic or endocrine disease
- Musculo-skeletal disabilities that would preclude treadmill walking
- Abnormal electrocardiogram (EKG) and heart health history
- Hematocrit below 32%
- Hormone replacement therapy
- Failure to conform to study protocol
Key Trial Info
Start Date :
May 15 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 19 2010
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04063813
Start Date
May 15 2007
End Date
August 19 2010
Last Update
August 21 2019
Active Locations (1)
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1
Michigan Clinical Research Unit United States
Ann Arbor, Michigan, United States, 48109