Status:
COMPLETED
Repetitive Transcranial Magnetic Stimulation in Post Stroke Upper Limb Spasticity
Lead Sponsor:
Izmir Katip Celebi University
Conditions:
Spasticity as Sequela of Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The reticulospinal pathway (RSP) is at the center of spasticity mechanism. The RSP indirectly synapses with motor neurons via interneurons in the ventromedial intermediate zone in both halves of the s...
Detailed Description
Spasticity is a disorder characterized by increase in velocity-related muscle tone as a part of upper motor neuron syndrome. Although the mechanisms underlying stroke-related spasticity have not been ...
Eligibility Criteria
Inclusion
- ≥ 18 years
- Stroke history ≥ 1 year
- Having a first stroke
- Grade 2 or 3 muscle tone according to the Modified Ashworth Scale (MAS) assessment in at least one of the elbow, wrist and finger flexors
- Signed consent to participate in the study
Exclusion
- To have a clinical condition (metallic implant, cardiac pace, pregnancy, breastfeeding, claustrophobia, epilepsy, head trauma, cranial operation history) that will constitute a contraindication to transcranial magnetic stimulation
- Presence of malignancy
- Pregnancy or breastfeeding
- Non-stroke disease or lesion affecting the sensorimotor system
- Presence of pump/shunt
- Advanced cognitive impairment
- To have been rehabilitated in the last 3 months
- Botulinum toxin injection in the last 3 months
- Taking systemic antispastic drugs (Patients taking these drugs may be included in the study after a period of at least 3 times the half-life of the drug used if they agree to quit)
- Previously treated with TMS
Key Trial Info
Start Date :
September 9 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 27 2021
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT04063995
Start Date
September 9 2019
End Date
June 27 2021
Last Update
April 1 2022
Active Locations (1)
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1
İlker Şengül
Izmir, Turkey (Türkiye), 35360