Status:
COMPLETED
Anabolic Potential of 3-hydroxybutyrate (3-OHB) and Whey Protein in a Human Catabolic Inflammatory Disease Model
Lead Sponsor:
University of Aarhus
Collaborating Sponsors:
Arla Foods Ingredients
Aarhus University Hospital
Conditions:
Endotoxemia
Muscle Loss
Eligibility:
MALE
20-40 years
Phase:
NA
Brief Summary
This study aims to investigate the muscle anabolic potential of adding ketone (3-hydroxybutyrate) to whey protein compared with isocaloric, isonitrogenous whey protein in a human model of inflammatory...
Detailed Description
Background: Muscle wasting during hospitalization is caused by a combination of immobilization (bed rest), hypocaloric diet and inflammation (e.g. sepsis), and preventive measures are needed. Whey pro...
Eligibility Criteria
Inclusion
- Between 20-40 years of age
- Body mass index between 20-30 kg/m\^2
- Healthy
- Oral and written consent forms obtained prior to study day
Exclusion
- Recent immobilization of an extremity that is not fully rehabilitated
- Lactose, lidocain or rubber allergies
- Current disease
- Use of anabolic steroids
- Smoking
- Former major abdominal surgery (Or current problems with the GI tract)
- \>10 hours of exercise/weak
- Present ketogenic diets or high-protein diets
- Blood doner that does not want to discontinue blood donations until study completion
- Pending MR scan
Key Trial Info
Start Date :
June 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 23 2020
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT04064268
Start Date
June 17 2019
End Date
January 23 2020
Last Update
June 11 2020
Active Locations (1)
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1
Medical Research Laboratory, DoH, Aarhus University Hospital
Aarhus, Denmark, 8000