Status:
TERMINATED
Scar Location and Acute Haemodynamic Response to MultiPoint Pacing Study in Patients With Ischemic Cardiomyopathy
Lead Sponsor:
Oxford University Hospitals NHS Trust
Collaborating Sponsors:
National Institute for Health Research, United Kingdom
Conditions:
Heart Failure
Ischemic Cardiomyopathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiac Resynchronization Therapy (CRT) is a proven treatment for heart failure. CRT consists of a special pacemaker with two/three leads (insulated wires which take the electrical impulses from the ...
Detailed Description
A prospective single-centre pilot study will be conducted to investigate this topic. Fifteen patients, with a history of previous ST Elevation Myocardial Infarction (STEMI) resulting in myocardial sca...
Eligibility Criteria
Inclusion
- Age of 18 years or over
- Previous STEMI (\> 3 months before enrolment) and consequent LV scar;
- Standard indication to CRT-D (NYHA functional class III-IV despite optimal medical therapy, LV ejection fraction (LVEF) ≤35 %, QRS duration ≥120 msec, LBBB);
- Sinus rhythm;
- Will and ability to give informed consent for participation in the study.
Exclusion
- Pregnancy, trying for a baby or breast feeding;
- Any other significant disease or disorder which, in the opinion of the investigator, may either put the participants at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate in the study;
- Inability to tolerate MRI scanning (e.g. claustrophobia, unable to lie flat)
- Contraindications to MRI scanning (e.g. implantable devices, cranial aneurysm clips, metallic ocular foreign bodies, hypersensitivity to gadolinium);
- Significantly impaired renal function (eGFR \< 30ml/min);
- History of allergy to cardiac MRI contrast media;
- Severe claustrophobia.
Key Trial Info
Start Date :
September 27 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2020
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT04066738
Start Date
September 27 2017
End Date
March 30 2020
Last Update
May 18 2022
Active Locations (1)
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1
John Radcliffe Hospital
Oxford, United Kingdom, OX3 9DU