Status:
COMPLETED
Ellagic Acid, Urolithin and Colonic Microbial Communities Affected by Walnut Consumption
Lead Sponsor:
UConn Health
Collaborating Sponsors:
American Institute for Cancer Research
California Walnut Commission
Conditions:
Colo-rectal Cancer
Colon Cancer
Eligibility:
All Genders
50-65 years
Phase:
NA
Brief Summary
Briefly, this is a 28-day dietary intervention study participants will be asked to eat 2 ounces (52 grams) of walnuts every day for 3 weeks, and at the end of the study period they will come in for a ...
Detailed Description
The investigators propose to address the influence of ellagic acid obtained from walnuts and its microbial-derived metabolites (urolithin) on the gut microbiome and inflammation-related biomarkers in ...
Eligibility Criteria
Inclusion
- Men or women between the ages of 50-65 years old who are scheduled to undergo a routine screening colonoscopy
- English speaking/reading patients willing and able to provide written informed consent for study participation
- Patients willing to consume walnuts for 3 weeks
- Willingness to comply with all study requirements
Exclusion
- Current active malignancy, previous history of gastrointestinal malignancy, or altered gastrointestinal anatomy
- Current evidence or previous history of ulcerative colitis or Crohn's disease
- HIV infection, chronic viral hepatitis
- Allergy to walnuts or hypersensitivity to tree nuts
- Use of antibiotics within the past month
- Individuals with blood coagulation disorders or on anti-coagulant therapy
- Treated with steroids, immunosuppressive agents or other anti-inflammatory drugs one week prior to starting intervention
- Non-English-speaking patients who require an interpreter to give consent
- Patients residing in the Department of Correction
- Inability to comply with the protocol requirements
- Any other condition that, in the opinion of the PI, might interfere with study objectives
Key Trial Info
Start Date :
May 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 8 2021
Estimated Enrollment :
47 Patients enrolled
Trial Details
Trial ID
NCT04066816
Start Date
May 20 2019
End Date
April 8 2021
Last Update
November 26 2021
Active Locations (1)
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1
University of Connecticut Health Center
Farmington, Connecticut, United States, 06030