Status:
COMPLETED
Effect of Photodynamic Treatment on Skin Microbiome. Single Center Study
Lead Sponsor:
University of Zurich
Conditions:
Postoperative Wound Infection Deep Incisional Surgical Site
Prosthesis and Implants
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if photodynamic therapy has an effect on bacterial skin colonization...
Detailed Description
Background. Periprosthetic joint infections are increasing due to our elderly population with the need of a joint prosthesis. These infections are difficult to treat, because bacteria are able to be s...
Eligibility Criteria
Inclusion
- Healthy male and female participants ≥ 18 years who
- volunteer for the pilot study in which a routine photodynamic treatment in the Department of Dermatology will be applied and effect of skin colonization will be analyzed, and
- an informed consent is signed by the participant (after information about the project).
Exclusion
- Pregnant and lacting women
- Participants with inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.,
- Participants taking antibiotics in the 14 days prior to the photodynamic treatment or until follow-up at 21 days
- Participants who received oral retinoid therapy within the last 6 months
- Participants who received anti-inflammatory agents as NSAR within the 14 days prior and after the PDT
- Participants taking any photosensitizing drugs within 4 weeks prior to the photodynamic treatment (PDT)
- Participants who had a history of photosensitivity disorder
- Fitzpatrick's skin phototype V-VI
Key Trial Info
Start Date :
September 26 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2021
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04067843
Start Date
September 26 2019
End Date
September 1 2021
Last Update
May 18 2022
Active Locations (1)
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1
University Hospital of Zurich
Zurich, Switzerland