Status:
COMPLETED
Cytomegalovirus Infection in Patients With HIV-1 Infection
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Cytomegalovirus Infections
HIV-1-infection
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to assess the level of CD4 and CD8 T cell activation in an observational cohort study of HIV-1 patients, virosuppressed on combined antiretroviral therapy (\< 50 copies/ml...
Detailed Description
T cell activation plays a central role in HIV pathogenesis and is highly correlated to disease progression even in HIV patients virosuppressed on combined antiretroviral therapy since years. The mecha...
Eligibility Criteria
Inclusion
- Patients included in the Aquitaine ANRS CO3 cohort aged 18 years or older (confirmed HIV-1 infection and at least one follow-up in the cohort),
- plasma HIV-1 RNA \<50 copies / ml for at least 24 months under a highly active antiretroviral combination (treatment comprising at least 3 antiretroviral drugs) modified or initiated between 2005 and 2008,
- Follow-up in one of the departments of Bordeaux University Hospital or Libourne Hospital,
- Free, informed and written consent, signed by the patient and the investigator (Consent of the Aquitaine CO3 Cohort and linked to this specific study).
Exclusion
- Presence of 2 consecutive measurements of HIV RNA\> 50 copies / ml,
- History of immunotherapy treatments (interleukin-2),
- Hepatitis B or C co-infections,
- Pregnancy
- Breastfeeding
- Symptomatic infectious episode in progress.
Key Trial Info
Start Date :
February 16 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 13 2010
Estimated Enrollment :
392 Patients enrolled
Trial Details
Trial ID
NCT04067869
Start Date
February 16 2010
End Date
December 13 2010
Last Update
August 28 2019
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