Status:
ACTIVE_NOT_RECRUITING
COLUMBIA-1: Novel Oncology Therapies in Combination With Chemotherapy and Bevacizumab as First- Line Therapy in MSS-CRC
Lead Sponsor:
MedImmune LLC
Conditions:
Metastatic Microsatellite-stable Colorectal Cancer
Eligibility:
All Genders
18-101 years
Phase:
PHASE1
PHASE2
Brief Summary
COLUMBIA-1 is a Phase 1b/2 platform study to evaluate the safety and efficacy of standard of care (FOLFOX plus bevacizumab) alone and in combination with novel oncology therapies in first-line metasta...
Detailed Description
COLUMBIA-1 is a Phase 1b/2, open-label, multicenter, randomized, multidrug platform study to evaluate the safety and efficacy of standard of care (FOLFOX plus bevacizumab) in combination with novel on...
Eligibility Criteria
Inclusion
- Written informed consent and any locally required authorization obtained from the participant/legal representative prior to performing any protocol-related procedures, including screening evaluations.
- Age ≥ 18 years at the time of screening.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Participants must have histologic documentation of advanced or metastatic CRC and: (a) A documented mutation test during screening and confirmed tumor locations from disease assessment for enrollment. (b) Participants must NOT have defective deoxyribonucleic acid (DNA) mismatch repair (MSI) as documented by testing. (c) Participants must not have received any prior systemic therapy for recurrent/metastatic disease (prior adjuvant chemotherapy or radio-chemotherapy is acceptable so long as progression was not within 6 months of completing the adjuvant regimen).
- Participants must have at least one lesion that is measurable by RECIST v1.1 (Eisenhauer et al, 2009).
- Participants must have adequate organ function.
- Participants with medical conditions requiring systemic anticoagulation (eg, atrial fibrillation) are eligible provided that both of the following criteria are met: - The participant has an in-range International Normalized Ratio (INR) on a stable dose of oral anticoagulant or be on a stable dose of low molecular weight heparin. - The participant has no active bleeding or pathological condition that carries a high risk of bleeding.
- Body weight \>35 kg.
- Adequate method of contraception per protocol.
Exclusion
- History of allogeneic organ transplantation.
- Active or prior documented autoimmune disorders within the past 5 years.
- History of venous thrombosis within the past 3 months.
- Cardiovascular criteria: (a) Presence of acute coronary syndrome including myocardial infarction or unstable angina pectoris, other arterial thrombotic event including cerebrovascular accident or transient ischemic attack or stroke within the past 6 months. (b) New York Heart Association (NYHA) class II or greater congestive heart failure, serious cardiac arrhythmia requiring medication, or uncontrolled hypertension. (c) History of hypertensive crisis/hypertensive encephalopathy within the past 6 months.
- Mean QT interval corrected for heart rate using Fridericia's formula (QTcF) ≥ 470 ms.
- No significant history of bleeding events or gastrointestinal perforation.
- Uncontrolled intercurrent illness.
- History of another primary malignancy except for: (a) Malignancy treated with curative intent and with no known active disease ≥ 5 years of low potential risk for recurrence. (b) Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease. (c) Adequately treated carcinoma in situ without evidence of disease.
- History of active primary immunodeficiency.
- Active infection including tuberculosis, hepatitis B, hepatitis C, or human immunodeficiency virus.
- Known allergy or hypersensitivity to any of the study drugs or any of the study drug excipients.
- Any unresolved toxicity National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) Grade \> 1 from previous anticancer therapy.
- History of leptomeningeal disease or cord compression.
- Untreated central nervous system (CNS) metastases.
- Lack of physical integrity of the upper gastrointestinal tract, malabsorption syndrome, or inability to take oral medication.
- Known dihydropyrimidine dehydrogenase (DPD) deficiency.
- Prior immunotherapy or anti-angiogenics.
- Receipt of live attenuated vaccine within the past 30 days.
- Major surgical procedure, open biopsy, or significant traumatic injury within the past 28 days.
- Current or prior use of immunosuppressive medication within the past 14 days, with exceptions per protocol.
Key Trial Info
Start Date :
September 13 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 24 2026
Estimated Enrollment :
61 Patients enrolled
Trial Details
Trial ID
NCT04068610
Start Date
September 13 2019
End Date
November 24 2026
Last Update
December 11 2025
Active Locations (21)
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1
Research Site
Los Angeles, California, United States, 90095
2
Research Site
Sacramento, California, United States, 95817
3
Research Site
Ann Arbor, Michigan, United States, 48109
4
Research Site
Las Vegas, Nevada, United States, 89169