Status:
COMPLETED
Relationship Between Heme Oxygenase 1 Enzyme Level and Coronary SYNTAX Score
Lead Sponsor:
Yeditepe University Hospital
Conditions:
Coronary Artery Disease
Oxidative Stress
Eligibility:
All Genders
18+ years
Brief Summary
Aim of this study is to investigate the relationship between heme oxygenase-1 enzyme level and angiographically determined SYNTAX score in patients with suspected stable coronary artery disease. Conse...
Detailed Description
Heme oxygenase-1(HO-1) is an enzyme found throughout the body with highest concentrations in tissues of reticuloendothelial system. It degrades heme to biliverdin and produces ferrous iron and carbon ...
Eligibility Criteria
Inclusion
- Patients with suspected stable coronary artery disease who are deemed to undergo coronary angiographic evaluation
Exclusion
- Patients with history of coronary bypass or other cardiac surgery
- Patients with acute coronary syndrome
- Patients with severe comorbid illnesses including active malignancies, stage 3-5 chronic renal failure, chronic obstructive lung disease
- Patients with clinically overt infectious or inflammatory diseases
- Patients taking medications that possibly interact with heme metabolism
- patients with hemoglobinopathies
Key Trial Info
Start Date :
October 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 30 2020
Estimated Enrollment :
159 Patients enrolled
Trial Details
Trial ID
NCT04070014
Start Date
October 1 2019
End Date
March 30 2020
Last Update
June 22 2020
Active Locations (1)
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1
Yeditepe University Hospital
Istanbul, Turkey (Türkiye)