Status:
COMPLETED
Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility
Lead Sponsor:
Lebanese University
Conditions:
Female Infertility
Female Infertility Due to Ovulatory Disorder
Eligibility:
FEMALE
21-44 years
Phase:
PHASE1
PHASE2
Brief Summary
The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (t...
Detailed Description
One in six couples worldwide is affected by infertility, which defined as the inability to conceive after one year or more of regular and unprotected intercourse. It has been stated that 48.5 million ...
Eligibility Criteria
Inclusion
- must not show any of the excluded criteria
- Patients affected by female infertility due to particularly Ovulatory Disorder, Premature Ovarian Failure, Polycystic Ovary Syndrome, Tubal Origin, Ectopic Pregnancy, Salpingitis, Tubal Block/Occlusion, Hydrosalpinx, Cervical/Vaginal, Endocrine, Endometriosis, Fibroids, Congenital Uterine Anomaly, Infections Uterine, and Female Infertility of Other Origin
- The selection of subjects' age must be group matched between protocols of treatment. Premature ovarian failure is defined as AMH (Anti Mullerian Hormone) ≤ 2 ng/mL.
- Willing to collaborate and to attend to the clinical follow-ups for the next three years
- Patients willing to sign informed consent
- Able and willing to comply with all study requirements
- Absence of genetic causes
- Medically suitable to undergo ovarian stimulation
- Normal serum chemistry and hematology screening tests
- Negative human immunodeficiency virus (HIV), hepatitis B (HBV), hepatitis C (HCV) serology
- No history of malignancy
- Complete history \& physical examination
Exclusion
- Subjects to be excluded from the study if the male (husband) had any male infertility problem(s)
- Patients with any genetic abnormalities
- Patients with histories of neurologic conditions including moderate or severe head injury, stroke, cerebral or bone damage or malignancies, brain abnormalities, learning disability, major medical or psychiatric illness, and metabolic/cardiovascular disease or evidence of cardiac/renal damage or malignancies, alcohol, loss of weight during the last 2 years, chemotherapy or immunosuppressive therapy.
- Women aged 45 years and older, under 21 years
Key Trial Info
Start Date :
February 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 5 2023
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04071574
Start Date
February 1 2018
End Date
May 5 2023
Last Update
May 9 2023
Active Locations (1)
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1
Lebanese University, faculty of sciences III
Tripoli, North Lebanon, Lebanon, 961