Status:
COMPLETED
Matrix Metalloproteinases and Human Papillomavirus in Dysplasias and Cancers of the Cervix
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Papillomavirus Infections
Dysplasia
Eligibility:
FEMALE
20-65 years
Phase:
NA
Brief Summary
This study aims to compare the expression of matrix metalloproteinases and their tissue inhibitors between 4 groups of patients defined according to the severity of the cervical lesion.
Detailed Description
Cervical cancer is the second most common cancer among European women under 45 years old. It is secondary to cervical dysplasia induced by persistent human papillomavirus infection. The involvement of...
Eligibility Criteria
Inclusion
- For control group:
- Age between 20 and 65 years
- Patients hospitalized for partial or total removal of the cervix
- Absence of cervical lesion observed on biopsy or hysterectomy
- Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study)
- Affiliate or beneficiary of a social security scheme
- For dysplasia and cancer group:
- Age between 20 and 65 years
- Cervical Intraepithelial Neoplasia or previously untreated cervical cancer
- Free, informed and written consent, dated and signed by the patient and the investigator (at the latest before any examination required by the study)
- Affiliate or beneficiary of a social security scheme
Exclusion
- For control group:
- History of laser or conisation
- Known antecedent of HIV infection
- Congenital or acquired immunodepression
- Long-term treatment with corticosteroids or immunosuppressants
- Persons placed under the protection of justice
- For dysplasia and cancer group:
- History of laser or conisation
- Pre-treatment of invasive cancers by radiotherapy or chemotherapy
- Known antecedent of HIV infection
- Congenital or acquired immunodepression
- Long-term treatment with corticosteroids or immunosuppressants
- Persons placed under the protection of justice
Key Trial Info
Start Date :
October 10 2007
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2011
Estimated Enrollment :
216 Patients enrolled
Trial Details
Trial ID
NCT04072913
Start Date
October 10 2007
End Date
January 31 2011
Last Update
August 28 2019
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