Status:
UNKNOWN
Electromechanical Profiling of the Long-QT Syndrome (LQTS)
Lead Sponsor:
Maastricht University Medical Center
Collaborating Sponsors:
University of Freiburg
University of Bern
Conditions:
Long QT Syndrome
Sudden Cardiac Death
Eligibility:
All Genders
18+ years
Brief Summary
High-resolution, non-invasive electromechanical mapping in genotyped long-QT syndrome patients and healthy controls at baseline and during smart provocation.
Detailed Description
Using simultaneous ECG-imaging, speckle-tracking analysis and tissue-phase mapping with MRI we will assess electromechanical dispersion at rest. Regional electromechanical elasticity will be investiga...
Eligibility Criteria
Inclusion
- LQTS group (Group 1):
- Diagnosis of LQTS according to the ESC guidelines.
- Genetic testing either already performed or consent to genetic testing (at least 5 major LQTS-related genes tested: KCNQ1, KCNH2, SCN5A, KCNE1, KCNE2).
- Control group (Group 2):
- \> Control subjects with structurally normal hearts.
Exclusion
- Pregnancy, nursing or planning to become pregnant.
- Known allergy or strong reaction to skin electrodes or contrast agent.
- Inability to give informed consent.
- Presence of metal objects in or attached to the body.
- Dialysis.
- Cardiomyopathy.
- Second-degree heart block or higher degrees of block.
- Sick sinus syndrome.
- Asthma.
- Chronic obstructive pulmonary disease.
- Left-main coronary artery disease.
- Unstable coronary artery disease.
Key Trial Info
Start Date :
January 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2022
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04074122
Start Date
January 1 2020
End Date
January 1 2022
Last Update
August 29 2019
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