Status:
UNKNOWN
Effects of Continuous Treatment With Rifaximin and Probiotics on the Gut Microbiota of Patients With IBS-D
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University
Collaborating Sponsors:
Sir Run Run Shaw Hospital
The First Affiliated Hospital of Zhejiang Chinese Medical University
Conditions:
IBS - Irritable Bowel Syndrome
Gut Microbiota
Eligibility:
All Genders
18-85 years
Phase:
PHASE4
Brief Summary
We will use the latest Rome IV criteria to recruit IBS-D patients and evaluate the effects of repeated treatment with rifaximin and sequential treatment with rifaximin and probiotics on different symp...
Detailed Description
According to the Rome IV diagnostic criteria, 200 patients with with diarrhoea-predominant irritable bowel syndrome (IBS-D) from the multi-center (8 units in the country) will be enrolled. The IBS Sev...
Eligibility Criteria
Inclusion
- 18-75 years old;
- in line with the diagnostic criteria of diarrhea-type irritable bowel syndrome Roman IV；
- blood routine, blood biochemistry, stool examination and colonoscopy within 2 years are no problem;
- no intestinal warning symptoms
Exclusion
- suffering from severe heart, lung, liver, kidney, nervous system diseases;
- suffering from mental disorders caused by schizophrenia, brain organic and physical diseases;
- suffering from other diseases that may affect intestinal function (such as diabetes, thyroid disease);
- History of previous abdominal surgery (excluding history of cholecystectomy or appendectomy);
- pregnant or lactating women;
- have undergone colonoscopy in the past month or accept other bowel preparation operations;
- In the past 1 month, have used antibiotics, antidiarrheal agents, intestinal flora regulation, Chinese medicine and other drugs;
- have participated in other dietary treatments;
- understand communication barriers, unable to communicate
Key Trial Info
Start Date :
May 10 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT04074421
Start Date
May 10 2020
End Date
December 1 2022
Last Update
July 28 2020
Active Locations (1)
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1
The Second Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China, 310009