Status:
UNKNOWN
Targeted T-cell Therapy in Solid Tumors
Lead Sponsor:
Benhealth Biopharmaceutical (Shenzhen) Co., Ltd.
Collaborating Sponsors:
Shenzhen Second People's Hospital
Conditions:
Malignant Solid Tumor
Eligibility:
All Genders
18-75 years
Phase:
EARLY_PHASE1
Brief Summary
This is a single-center, open, single-arm controlled prospective clinical trial of patients with solid tumors treated with targeted activation of T cells through intravenous infusion.The purpose of th...
Detailed Description
In China, malignant tumors have become the leading cause of death for urban and rural residents, with solid tumors accounting for 77 percent.Immunotherapy is considered one of the most promising ways ...
Eligibility Criteria
Inclusion
- Age: 18\~75 years old; 2. Patients with solid tumors still show progress after radiotherapy, chemotherapy and targeted therapy, with at least one measurable lesion; 3. No congenital autoimmune diseases or immunodeficiency diseases;' 4. At least one or more solid tumor targets of HER2, MUC1, CEA, EGFR and GPC3 were positive by immunohistochemical examination of tumor tissues; 5. No serious infectious diseases (hepatitis b, c, syphilis, AIDS); 6. Sign informed consent voluntarily. -
Exclusion
- The researchers determined that the patient could not complete 6 courses of treatment.
- 2\. Patients with t-cell lymphoma. 3. Pregnant or lactating female patients, or those who do not want to use contraception during the trial.
- 4\. Allergic to both CT and MRI contrast agents and unable to conduct imaging evaluation.
- 5\. Other patients in the treated group who were considered as unfit for cell therapy.
- \-
Key Trial Info
Start Date :
May 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2021
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04076137
Start Date
May 1 2019
End Date
May 1 2021
Last Update
September 3 2019
Active Locations (1)
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1
Department of oncology, the second people's hospital of shenzhen
Shenzhen, Guangdong, China, 518055