Status:
COMPLETED
Intrauterine Flushing With Follicular Fluid Plus Granulosa Cells
Lead Sponsor:
Royan Institute
Conditions:
Follicular Fluid
Granulosa Cell
Eligibility:
FEMALE
20-38 years
Phase:
PHASE3
Brief Summary
One hundred forty patients with male factor infertility are randomized into two groups. In the study group, flushing the endometrial cavity with 2ml of clear follicular fluid with granulose cells will...
Detailed Description
This study is a randomized clinical trial to investigate implantation rate and clinical pregnancy after intrauterine flushing of infertile patients with follicular fluid plus granulosa cells - Randomi...
Eligibility Criteria
Inclusion
- Normal Hormonal profile (FSH, LH, AMH) and normal AFC
- Normal ovarian reserve
- Age 20-38 years
- Regular menstrual cycle
- IVF / ICSI or IVF or ICSI cycles with agonist and antagonist protocol
- Existence of at least 2 oocytes in dominant follicular fluids
Exclusion
- Presence of Endometriosis and Endometrioma
- Hydrosalpinx
- OHSS (Ovarian Hyper Stimulating Syndrome)
- Tubal factor infertility
- Male factor infertility with azoospermia
- Low/Poor Response
- Myoma with a compression effect or submocusa myometrium
- Intra mural or subserouse Myoma \> 5cm
- Presence of untreated Thyroid, Diabetic and Hepatitis diseases, vaginal infection.
- Endometrial tuberculosis
- The follicular fluid which contains any oocyte or contaminated with blood will be discarded
Key Trial Info
Start Date :
November 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2023
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT04077970
Start Date
November 1 2018
End Date
January 1 2023
Last Update
March 14 2023
Active Locations (1)
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1
Royan Institute
Tehran, Iran