Status:
COMPLETED
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
Lead Sponsor:
Loughborough University
Conditions:
Inflammation
Obesity
Eligibility:
All Genders
18-40 years
Brief Summary
This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese. Blood and white adipose tissue samples will be collected in the ...
Eligibility Criteria
Inclusion
- 18-40 years
- Waist circumference/BMI criteria:
- Lean participants: waist circumference ≤94 cm (men) and 80 cm (women) and BMI ≥ 21.0 kg/m2 or
- Obese participants: waist circumference ≥102 cm (men) and 88 cm (women) and BMI ≥ 30.0kg/m2
- Recreationally active (\> 3 x 30 min moderate exercise per week)
- Blood pressure systolic blood pressure \<160 mmHg and diastolic blood pressure \<100 mmHg
Exclusion
- Smoker (including vaping)
- Cardiometabolic or inflammatory disease (e.g. heart disease, high blood pressure, type 2 diabetes)
- Taking medication or nutritional supplements (e.g. fish oil/prebiotics) known to interfere with study outcomes (including inflammation, immune function or lipid/carbohydrate metabolism) or prescribed antibiotics within the last 3 months
- Unstable weight history (≥ 3kg loss or gain in previous 3 months)
- An allergy to lidocaine (determined by the Schools standard health questionnaire)
- Parallel participation in another intervention study
- Women who are pregnant or lactating
- Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a metabolic study
- Alcohol consumption \>28 units per week for a man or \>21 units per week for a woman
Key Trial Info
Start Date :
October 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2020
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04078776
Start Date
October 25 2019
End Date
August 1 2020
Last Update
May 17 2022
Active Locations (1)
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1
Loughborough University
Loughborough, United Kingdom, LE11 3TU