Status:
COMPLETED
Essential Amino Acids and High Intensity Interval Training
Lead Sponsor:
University of North Carolina, Chapel Hill
Collaborating Sponsors:
National Strength and Conditioning Association
Conditions:
Cardiovascular Risk Factor
Obesity
Eligibility:
All Genders
30-50 years
Phase:
NA
Brief Summary
Purpose: The primary purpose is to determine the combined effects of essential amino acids (EAA) supplementation and high intensity interval training (HIIT) on body composition, muscle characteristics...
Eligibility Criteria
Inclusion
- Men and women (25-50 years).
- Overweight and obese: body mass index (BMI) of 27 - 40 kg·m-2 and/or percent body fat \> 25% for men, and BMI of 25 - 40 kg·m-2 and/or Percent Body Fat \> 30% for women.
- Healthy, non-smokers.
- Women: eumenorrheic, reporting consistent menstruation, having 3 regular cycles in the 3 months prior to enrollment, and not pregnant or planning on becoming pregnant.
Exclusion
- Have current and/or history of cardiovascular disease, diabetes, metabolic, thyroid, pulmonary, renal, hepatic, gastrointestinal, musculoskeletal disorders or medical or surgical events, such as bariatric surgery, heart surgery, or any joint or musculoskeletal surgeries occurring in the 6-months prior to enrollment, that may significantly influence study outcomes or prevent safe participation.
- Have uncontrolled hypertension or an abnormal electrocardiogram.
- Have a diagnosed mental disorder
- Inconsistently taking medications or taking medications that may influence study outcomes.
- Participating in more than 150 minutes per week of moderate exercise, more than 2 days per week of resistance training, or currently participating in high intensity interval training or participated in HIIT within the previous 12 weeks.
- Lost or gained greater than eight pounds within three months prior to the enrollment.
- Currently consuming a high protein diet (,1.6 g·kg-1·day-1 and \<25% of calories from protein).
- Currently consuming meal replacements or dietary supplements that may taurine, or beta-hydroxy beta-methylbutyrate) within eight weeks prior to the enrollment date.
- Reports any known sensitivity to the Essential Amino Acid treatment.
- Has participated in another clinical trial within four weeks prior to enrollment that in the opinion of the PI would influence the results.
- Has severely impaired hearing or speech or inability to speak English.
- Unwilling or unable to comply with the study protocol, including abstaining from, caffeine, tobacco, alcohol, and physical activity before testing days.
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 5 2020
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT04080102
Start Date
March 1 2019
End Date
January 5 2020
Last Update
April 30 2020
Active Locations (1)
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1
Applied Physiology Laboratory, Fetzer Hall Room 25
Chapel Hill, North Carolina, United States, 27599