Status:
COMPLETED
Mechanical Insufflation -Exsufflation in Children With NMD and Weak Cough
Lead Sponsor:
Oslo University Hospital
Conditions:
Neuromuscular Diseases in Children
Eligibility:
All Genders
6-18 years
Phase:
NA
Brief Summary
Neuromuscular diseases (NMD) in children are severe, possibly life-threatening orphan conditions. The children are vulnerable and often subject to rapid deterioration of pulmonary function due to impa...
Detailed Description
On the basis of a prevalence study and a bench study different settings will be studied in children with NMD and weak cough to examine if settings derived from the lung model, are optimal to increase ...
Eligibility Criteria
Inclusion
- Diagnosed neuromuscular disease \< 18 years
- Established use (\> 3mnd) of MI-E.
- Reduced PCF
- PCF \< 270 l/min (when \> 12 years)
- \< 5th percentiles for PCF 16 (when 4 - 12 years)
- Clinical indication (difficulty to clear secretions, audible weak cough, history of pneumonia or frequent or prolonged respiratory tract infections).
Exclusion
- age \< 6 mnd
- obstructive lung disease (hyperinflation or emphysema on x-ray.
Key Trial Info
Start Date :
January 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 28 2021
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT04081116
Start Date
January 1 2019
End Date
February 28 2021
Last Update
January 20 2023
Active Locations (4)
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1
Helse bergen HF
Bergen, Norway
2
Oslo university hospital
Oslo, Norway
3
Stavanger university hospital
Stavanger, Norway
4
St. Olav Trondheim university hospital
Trondheim, Norway