Status:
COMPLETED
Stimulation of Parieto-hippocampal Connectivity in Patients With Major Depressive Disorder
Lead Sponsor:
University Hospital, Bonn
Collaborating Sponsors:
Clemens Mielacher, University Hospital, Bonn
Conditions:
Depression
Depressive Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
This study aims to investigate the effects of individualized repetitive transcranial magnetic stimulation (rTMS) of parieto-hippocampal functional connectivity in patients with major depressive disord...
Eligibility Criteria
Inclusion
- fulfilled criteria for unipolar major depressive disorder for at least four weeks
- did not respond to a minimum of one or did not tolerate a minimum of two antidepressants in the current episode
Exclusion
- metal in the brain or the skull
- cardiac pacemaker or intracardiac lines
- medication infusion devices
- heart or brain surgery
- pregnancy
- substance induced depression
- history of substance abuse
- psychotic episodes
- bipolar disorder
- anorexia
- posttraumatic stress disorder (current or within the last 12 months)
- claustrophobia
- any condition resulting in increased intracranial pressure
- traumatic brain injury
- history of epilepsy
- cerebral aneurysms
- dementia
- Morbus Parkinson
- Chorea Huntington
- multiple sclerosis
- stroke or transient ischemic attack (within the last 2 years)
- previous antidepressive treatment with rTMS, electroconvulsive therapy (within the last 3 months), vagus nerve stimulation or deep brain stimulation
Key Trial Info
Start Date :
August 2 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 22 2018
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04081519
Start Date
August 2 2016
End Date
June 22 2018
Last Update
August 4 2021
Active Locations (1)
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1
Klinik und Poliklinik für Psychiatrie und Psychotherapie
Bonn, Germany